“Kan reactievermogen beïnvloeden – Ik kan dan uitslag krijgen of zoiets?” | Amsterdam University Press Journals Online
2004
Volume 45, Issue 1
  • ISSN: 1573-9775
  • E-ISSN: 2352-1236

Abstract

Abstract

Drug labels instructions are physically attached to each package dispensed to patients and consist of dosage instructions (e.g., ‘Take two capsules twice daily’), auxiliary warnings (e.g., ‘Do not drink alcoholic beverages’) and advices (e.g., ‘Take with food or milk’). They are often misinterpreted which may lead to incorrect drug use. The wordings of instructions are a cause of such misinterpretation, especially for people with limited health literacy. In a qualitative study, we explored pharmacy visitors’ interpretations of drug label instructions and their opinions on potential improvements. Semi-structured interviews were conducted with 39 pharmacy visitors with limited and adequate health literacy. They received seven drug label instructions and explained them in their own words and demonstrated how much and how often they would take the drugs on a timetable. Although pharmacy visitors were able to explain dosage instructions, they often made mistakes in demonstrating them, especially those with limited health literacy. Medical jargon (e.g., ‘drowsiness’) and difficult words (e.g., ‘maximum’) lead to misinterpretations, especially among pharmacy visitors with limited health literacy. When optimizing drug label instructions, a trade-off must be made between the comprehensibility and the nuance of instructions.

Loading

Article metrics loading...

/content/journals/10.5117/TVT2023.3.004.HOOI
2023-12-01
2024-07-03
Loading full text...

Full text loading...

/deliver/fulltext/15739775/45/1/TVT2023.1.004.HOOI.html?itemId=/content/journals/10.5117/TVT2023.3.004.HOOI&mimeType=html&fmt=ahah

References

  1. Aspden, P., Wolcott, J. A., Bootman, J. L., & Cronenwett, L. R. (2006). Preventing medication errors (pp. 409-46). Washington, DC: National Academies Press.
    [Google Scholar]
  2. Bailey, S. C., Navaratnam, P., Black, H., Russell, A. L., & Wolf, M. S. (2015). Advancing best practices for prescription drug labeling. Annals of Pharmacotherapy, 49(11), 1222-1236.
    [Google Scholar]
  3. Bailey, S. C., Sarkar, U., Chen, A. H., Schillinger, D., & Wolf, M. S. (2012). Evaluation of language concordant, patient-centered drug label instructions. Journal of General Internal Medicine, 27(12), 1707-1713.
    [Google Scholar]
  4. Bailey, S. C., Wolf, M. S., Lopez, A., Russell, A., Chen, A. H., Schillinger, D., … & Sarkar, U. (2014). Expanding the Universal Medication Schedule: a patient-centred approach. BMJ open, 4(1), e003699.
    [Google Scholar]
  5. Berkman, N. D., Sheridan, S. L., Donahue, K. E., Halpern, D. J., & Crotty, K. (2011). Low health literacy and health outcomes: an updated systematic review. Annals of Internal Medicine, 155(2), 97-107.
    [Google Scholar]
  6. Borgsteede, S. D., & Heringa, M. (2019). Nature and frequency of dosing instructions on prescription labels in primary care. Pharmacoepidemiology and Drug Safety, 28(8), 1060-1066.
    [Google Scholar]
  7. Bostock, S., & Steptoe, A. (2012). Association between low functional health literacy and mortality in older adults: longitudinal cohort study. BMJ, 344:e1602
    [Google Scholar]
  8. Botermann, L., Krueger, K., Eickhoff, C., Kloft, C., & Schulz, M. (2016). Patients’ handling of a standardized medication plan: a pilot study and method development. Patient preference and adherence, 10, 621-630.
    [Google Scholar]
  9. Davis, T. C., Federman, A. D., Bass, P. F., Jackson, R. H., Middlebrooks, M., Parker, R. M., & Wolf, M. S. (2009). Improving patient understanding of prescription drug label instructions. Journal of General Internal Medicine, 24, 57-62.
    [Google Scholar]
  10. DavisT.C., LongS.W., JacksonR.H., MayeauxE.J., GeorgeR.B., MurphyP.W., CrouchM.A. (1993). Rapid estimate of adult literacy in medicine: a shortened screening instrument. Family Medicine, 25(6), 391-395.
    [Google Scholar]
  11. Davis, T. C., Wolf, M. S., Bass, P. F., Thompson, J. A., Tilson, H. H., Neuberger, M., & Parker, R. M. (2006). Literacy and misunderstanding prescription drug labels. Annals of Internal Medicine, 145(12), 887-894.
    [Google Scholar]
  12. European Commission, Consumer Goods Pharmaceuticals (2009). Guideline on the Readability of the Labeling and Package Leaflet of Medicinal Products for Human Use (Brussels: European Commission, 2009).
    [Google Scholar]
  13. Fransen, M. P., Leenaars, K. E., Rowlands, G., Weiss, B. D., Maat, H. P., & Essink-Bot, M. L. (2014). International application of health literacy measures: Adaptation and validation of the newest vital sign in The Netherlands. Patient Education and Counseling, 97(3), 403-409.
    [Google Scholar]
  14. Koster, E. S., Blom, L., Winters, N. A., Van Hulten, R. P., & Bouvy, M. L. (2014). Interpretation of drug label instructions: A study among four immigrants groups in the Netherlands. International Journal of Clinical Pharmacy, 36(2), 274-281. https://doi.org/10.1007/s11096-013-9873-x
    [Google Scholar]
  15. Koster, E. S., Philbert, D., & Bouvy, M. L. (2015). Health literacy among pharmacy visitors in the Netherlands. Pharmacoepidemiology and Drug Safety, 24(7), 716-721. https://doi.org/10.1002/pds.3803
    [Google Scholar]
  16. Lentz, L. R., & Pander Maat, H. (2010). Een leesbare bijsluiter. Tijdschrift voor Taalbeheersing, 32(2), 128-151.
    [Google Scholar]
  17. Locke, M. R., Shiyanbola, O. O., & Gripentrog, E. (2014). Improving prescription auxiliary labels to increase patient understanding. Journal of the American Pharmacists Association, 54(3), 267-274.
    [Google Scholar]
  18. Maghroudi, E., van Hooijdonk, C. M. J., van Dijk, L., Boland, G., de Haas, C., Journée-Gilissen, M., van der Velden, J., Vervloet, M., Westerhof, H., Rademakers, J. J. D. J. M., & Borgsteede, S. D. (2020). Development of Comprehensible Prescription Label Instructions: A Study Protocol for a Mixed-Methods Approach. Frontiers in Pharmacology, 11, [981].
    [Google Scholar]
  19. Maghroudi, E., Van Hooijdonk, C. M. J., Van de Bruinhorst, H., Van Dijk, L., Rademakers, J., & Borgsteede, S. D. (2021). The impact of textual elements on the comprehensibility of drug label instructions (DLIs): A systematic review. PloS one, 16(5), e0250238.
    [Google Scholar]
  20. Martins, S. F., van Mil, J. F., & Da Costa, F. A. (2015). The organizational framework of community pharmacies in Europe. International journal of clinical pharmacy, 37, 896-905.
    [Google Scholar]
  21. McCarthy, D. M., Davis, T. C., King, J. P., Mullen, R. J., Bailey, S. C., Serper, M., … & Wolf, M. S. (2013). Take-Wait-Stop: a patient-centered strategy for writing PRN medication instructions. Journal of Health Communication, 18(sup1), 40-48.
    [Google Scholar]
  22. NijmanJ., HendriksM., BrabersA., JongJ. de, & RademakersJ. (2014). Patient activation and health literacy as predictors of health information use in a general sample of Dutch health care consumers. Journal of Health Communication: International Perspectives, 19(8), 955-969.
    [Google Scholar]
  23. Nutbeam, D. (2000). Health literacy as a public health goal; a challenge for contemporary health education and communication strategies into 21st century. Health Oromotion International, 15(3), 259-267.
    [Google Scholar]
  24. NutbeamD. (2009). Defining and measuring health literacy: what can we learn from literacy studies?Int. J. Public Health, 54(5), 303–305.
    [Google Scholar]
  25. Pires, C., Vigário, M., & Cavaco, A. (2016). Factors influencing subjects’ comprehension of a set of medicine package inserts. International Journal of Clinical Pharmacy, 38, 888-898.
    [Google Scholar]
  26. Rademakers, J. (2014). Kennissynthese: gezondheidsvaardigheden: niet voor iedereen vanzelfsprekend. NIVEL
    [Google Scholar]
  27. Samaranayake, N. R., Bandara, W. G., & Manchanayake, C. M. (2018). A narrative review on do’s and don’ts in prescription label writing–lessons for pharmacists. Integrated Pharmacy Research and Practice, 53-66.
    [Google Scholar]
  28. Sahm, L. J., Wolf, M. S., Curtis, L. M., Behan, R., Brennan, M., Gallwey, H., & Mc Carthy, S. (2012). What’s in a label? An exploratory study of patient-centered drug instructions. European Journal of Clinical Pharmacology, 68(5), 777-782
    [Google Scholar]
  29. SørensonK, Van den BrouckeS, FullamJ, DoyleG, PelikanJ., et al. (2012). Health literacy and public health: a systematic review and integration of definitions and models. BMC Public Health, 25, 12:80.
    [Google Scholar]
  30. Sturkenboom, M. C. J. M., Van Den Bemt, P. M. L. A., De Smet, P. A. G. M., & Hek, K. (2017). Eindrapport: Vervolgonderzoek Medicatieveiligheid. Erasmus MC, NIVEL, Radboud UMC en PHARMO
    [Google Scholar]
  31. Talevski, J., Wong Shee, A., Rasmussen, B., Kemp, G., & Beauchamp, A. (2020). Teach-back: A systematic review of implementation and impacts. PloS one, 15(4), e0231350.
    [Google Scholar]
  32. Van Mil, J. F. (2005). Pharmaceutical care in community pharmacy: practice and research in the Netherlands. Annals of Pharmacotherapy, 39(10), 1720-1725.
    [Google Scholar]
  33. Webb, J., Davis, T. C., Bernadella, P., Clayman, M. L., Parker, R. M., Adler, D., & Wolf, M. S. (2008). Patient-centered approach for improving prescription drug warning labels. Patient Education and Counseling, 72(3), 443-449.
    [Google Scholar]
  34. Weiss, B. D., Mays, M. Z., Martz, W., Castro, K. M., DeWalt, D. A., Pignone, M. P., et al. (2005). Quick assessment of literacy in primary care: the newest vital sign. The Annals of Family Medicine, 3(6), 514-522.
    [Google Scholar]
  35. Willems, A. E. M., Heijmans, M., Brabers, A. E. M., & Rademakers, J. (2022). Gezondheidsvaardigheden in Nederland: factsheet cijfers 2021.
    [Google Scholar]
  36. Wolf, M. S., Davis, T. C., Curtis, L. M., Bailey, S. C., Knox, J. P., Bergeron, A., … & Wood, A. J. (2016). A patient-centered prescription drug label to promote appropriate medication use and adherence. Journal of General Internal Medicine, 31, 1482-148.
    [Google Scholar]
  37. Wolf, M. S., Davis, T. C., Curtis, L. M., Webb, J. A., Bailey, S. C., Shrank, W. H., … & Wood, A. J. (2011). Effect of standardized, patient-centered label instructions to improve comprehension of prescription drug use. Medical care, 49(1), 96-100.
    [Google Scholar]
  38. Wolf, M. S., Davis, T. C., Shrank, W., Rapp, D. N., Bass, P. F., Connor, U. M., … & Parker, R. M. (2007). To err is human: patient misinterpretations of prescription drug label instructions. Patient Education and Counseling, 67(3), 293-300.
    [Google Scholar]
  39. Wolf, M. S., Davis, T. C., Tilson, H. H., Bass III, P. F., & Parker, R. M. (2006). Misunderstanding of prescription drug warning labels among patients with low literacy. American Journal of Health-System Pharmacy, 63(11), 1048-1055.
    [Google Scholar]
  40. Yuan, H. C. T., Raynor, D. K., & Aslani, P. (2019). Comparison of international regulations for written medicine information (WMI) on prescription medicines. Therapeutic Innovation & Regulatory Science, 53, 215-226.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5117/TVT2023.3.004.HOOI
Loading
/content/journals/10.5117/TVT2023.3.004.HOOI
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error